Kawasaki disease OX40–OX40L axis acts as an upstream regulator of NFAT signaling pathway

Mathematics of the NFAT Signaling Pathway

This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and Höfer using a large system of ordinary differential equations depending on many parameters. With the help of chemical rea...

The Roles of Ca2+/NFAT Signaling Genes in Kawasaki Disease: Single- and Multiple-Risk Genetic Variants

Ca(2+)/nuclear factor of activated T-cells (Ca(2+)/NFAT) signaling pathway may play a crucial role in Kawasaki disease (KD). We investigated 16 genetic variants, selected by bioinformatics analyses or previous studies, in 7 key genes involved in this pathway in a Chinese population. We observed a significantly or marginally increased KD risk associated with rs2720378 GC + CC genotypes (OR = 1.3...

Kawasaki Disease Presenting as Acute Clinical Hepatitis

Kawasaki disease is a systemic vasculitis of children. Among gastrointestinal symptoms of this disease jaundice occurs uncommonly. We present a 23 month boy with icter and clinical hepatitis and final diagnosis of kawasaki disease.

Transforming Growth Factor- Signaling Pathway in Patients With Kawasaki Disease

Calcium Signaling: Deciphering the Calcium–NFAT Pathway

Rapid cellular calcium oscillations activate gene expression hours later. How this temporal response amplification is achieved has until now been largely a mystery. An elegant combination of experimental strategies and a model that encompasses non-linear inputs and outputs now sheds new light on this long-standing problem.